[Paper] Twelve quick tips for designing AI-driven HPC workflows
Source: arXiv - 2606.07491v1
Overview
High-performance computing (HPC) clusters remain the backbone of large-scale scientific computation, traditionally executing deterministic, linear pipelines optimised for predictable performance. However, the pervasive integration of artificial intelligence (AI) and foundation models into scientific research has introduced a fundamentally new computational paradigm. AI-driven workflows are characteristically iterative, data-driven, and probabilistic, introducing unique challenges regarding data gravity, heterogeneous resource management, and complex workflow orchestration. This guide provides twelve practical tips designed to help researchers design efficient, scalable, and reproducible AI-driven HPC workflows. By addressing critical system-level bottlenecks - such as containerisation for environment portability, strategic deployment of job arrays, explicit feedback loop mechanics, and I/O optimisation for small files - this article offers a framework for transitioning from rigid execution pipelines to adaptive, intelligent computational environments. While these architectural principles are broadly applicable across distributed environments, they are particularly tailored to the resource-intensive throughput demands of modern computational biology.
Key Contributions
This paper presents research in the following areas:
- cs.DC
- cs.AI
- cs.LG
- cs.SE
Methodology
Please refer to the full paper for detailed methodology.
Practical Implications
This research contributes to the advancement of cs.DC.
Authors
- Jamie J. Alnasir
Paper Information
- arXiv ID: 2606.07491v1
- Categories: cs.DC, cs.AI, cs.LG, cs.SE
- Published: June 5, 2026
- PDF: Download PDF